These nonantimicrobial sulfonamides do not undergo metabolism to the N 4 -hydroxylated metabolite associated with SJS and will not bind to IgE at the N 1 position and, therefore, are unlikely to cause cross-reactivity, even in patients who have experienced type 1 hypersensitivity or serious non-type-1 hypersensitivity reactions to sulfonamide antimicrobial agents
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& Bouchelouche, P
(2014) Altered glutamate cysteine ligase expression and activity in renal cell carcinoma, Biomed
Since OCTs-mediated cellular uptake is concentrative and much more active than the Ctr1 type ( + -gradients, is involved in the efflux of Pt drugs as well as other endogenous or exogenous organic cations in the DRG ( In brief, Pt-associated transporter proteins determine the accumulation of Pt drugs in DRG and, thus, could be developed as therapeutic targets to prevent the development of PIPN
