4.2 Hyperthyroid-induced hepatic disease Hyperthyroid-induced hepatic disease involves liver injury caused by excessive thyroid hormones, resulting in hepatocellular degeneration, necrosis, and hepatomegaly (106), and often presents with jaundice, elevated transaminases, or cirrhosis (107)
Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory
GSH is ready to neutralize free radicals and support cellular functions
A full medical evaluation is required to determine candidacy, review contraindications, and ensure proper dosing and monitoring
Side effects are few but it can cause mild nausea if taken in large doses
Resuspended samples were then reacted with 20 mM TCEP for 3 min and then mixed with 40 mM IAM and further incubated at RT in the dark for 30 min