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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed for type 2 diabetes management and now increasingly prescribed for weight management
Conflict of Interests The authors declare no conflict of interest in this study
OH and OH can be formed from H 2 O 2 in a nonenzymatic reaction catalyzed by Fe 2+ (the Fenton reaction , reaction 7)
The weight loss+AOD 9604 group showed a 20% decrease in body weight and a 30% decrease in body fat percentage (enhanced fat loss effect)
However the down side to this increased mitochondrial function was that more oxidative damage occurred (3) , so the researchers decided to add the powerful mitochondrial antioxidant alpha lipoic acid (ALA) to the mix to see if they could get the best of both worlds: increased mitochondrial energy output, with reduced mitochondrial damage
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