May support fat utilization during physical activity
This negative effect seems to be smaller than that observed after RYGB (267)
Notably, LA, while remaining relatively stable in its solid state, undergoes polymerization when subjected to temperatures exceeding its melting point (47.5 C) or when dissolved in a neutral solution under the presence of light [30]
To this point, a review and meta analysis of 11 trials demonstrated significant improvements in various high-intensity exercise performance measures including time to exhaustion, work capacity, peak power, and number of repetitions and volume lifted in leg press exercises (2)
The reductions were driven by larger decreases of calorie-dense processed items, while purchases of nutrient-dense products like fresh fruits, vegetables and yogurts grew
In summary, to minimize pain, injectable formulations should aim for isotonicity, appropriate viscosity, near-physiological pH, and careful selection and concentration of buffers and preservatives