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Weighted gene co-expression network analysis (WGCNA) identified genotype-driven, rather than treatment-driven, gene modules, highlighting distinct transcriptional architectures between WT and KO animals
Okada, F
Distractions (01:00:17) Nutrition for Brain Health, Dementia
Adenosine Triphosphate
SHMT2 not only was found to be highly expressed in glioblastoma (GBM) (Kim et al., 2015), hepatocellular carcinoma (HCC) (Woo et al., 2016), colorectal cancer (CRC) (Wei et al., 2018), and diffuse large B-cell lymphoma (DLBCL) (Ducker et al., 2017) but also specifically promoted the growth and proliferation of tumor cells when the glycine cleavage system was not functioning properly (Kim et al., 2015)
This connection between the gut & pancreatic islets may be responsible for ~50% of postprandial insulin release (Perley & Kipnis, J Clin Invest 46:1954-1962
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