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Alternatively, a pre-existing small population of open conformations can accommodate the peptide hormone smoothly and this may trigger the transition of GLP-1R from the closed to the otherwise energetically unfavorable open conformation (Fig

doi: 10.1073/pnas.1415518111 106 WangXKimCSAdamsBCWilkinsonRHillMMShahAKet al

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serious but rare side effects may involve allergic responses

Author Contributions JL provided a full final draft of the section on the design of liraglutide and semaglutide

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