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40, 41 Studies in mice lacking mast cells (W/W v ) have helped clarifying the role of this cell type in arthritis as well as inflammation: these mice failed to produce an inflammatory and erosive arthritis after infusion of autoantibodies

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Delivery of therapeutics Viral delivery of CRISPR-Cas9 gene constructs and ASOs have been a commonly used method that utilizes vectors such as lentiviruses, adenoviruses, and adeno-associated viruses (AAV) [141] (Table 1)

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Unlike other drugs such as Mounjaro and Zepbound, which activate both GLP-1 and GIP receptors, MariTide works as a GLP-1 receptor agonist and a GIP receptor antagonist

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