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tremor Increased thyroxine (T 4 ), free T 4 , and free T 4 index Failure of thyroid suppression with triiodothyronine (T 3 ) admin-istration In Graves disease: goiter (often with bruit), ophthalmopathy GENERAL CONSIDERATIONS Hyperthyroidism (thyrotoxicosis) is a group of disorders characterized by increased free T 4 and/or T 3

In the context of PMOS, the oxidative stress connection is directly relevant: studies confirm that granulosa cells from PMOS patients exhibit obvious inflammation and oxidative stress, with significantly reduced proliferation and increased apoptosis

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Molecules 26(23):7337 Trovato M (2020) A historical excursus of diagnostic methods for Hashimoto thyroiditis and Graves disease

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