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Folate and nucleic acid metabolism The figure highlights that riboflavin in the form of flavin adenine dinucleotide (FAD) is a required cofactor for the enzyme methylenetetrahydrofolate reductase (MTHFR), which reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate

Kim YJ, Rho W-Y, Park S, Jun B-H

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et al., Bcl-2 and Glutathione Depletion Sensitizes B16 Melanoma to Combination Therapy and Eliminates Metastatic Disease [122], the in vivo effects of the combination of GSH and Bcl-2 depletion with various anticancer treatments (such as paclitaxel, X-rays, tumor necrosis factor-, and IFN-) were examined

This was not statistically significant (p = 0,21)