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Source: Healthline first month on GLP-1s Healthline's first-month GLP-1 guide notes that GLP-1 medications may reduce thirst and that nausea, vomiting, and diarrhea can increase dehydration risk

Water: 64 oz

Clinical symptoms of hyperammonemic encephalopathy often include acute alterations in level of consciousness and/or cognitive function with lethargy or vomiting

22 Additionally, keratinocytes secrete antimicrobial peptides, cytokines, and chemokines that cause immune cell infiltration

Do not administer intravenously or intramuscularly

This timing also reduces the chance that injection-related stress disrupts sleep, since anxiety about needles occasionally interferes with nighttime relaxation