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Nat Rev Endocrinol 22 , 383384 (2026)

Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms

Because the win isnt just in the weight lost - its in how you feel while getting there.

Its estimated that 23 million medical pens are incinerated or landfilled every year

Dysregulation of this pathway is implicated in the progression of MASLD, MASH, and hepatocellular carcinoma (HCC) (Chen et al

Basically, GLP-1 helps keep the gut and intestines working correctly to maintain healthy blood sugar levels as well as affecting the part of the brain that creates satiety (or feeling full) and curbs cravings, which is all important when maintaining or getting to a healthy weight