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Similar to albumin, AAT has exposed methionine (Met) residues and a free cysteine at the position 232, which can be attacked by oxidants

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Owing to donor-to-donor variability associated with human samples, we repeated this protocol in additional sets of islets from humans that spanned a range of BMI, age and HbA1C%, and included donors of both sexes (Extended Data Table 2)

Patients who meet the clinical criteria can be prescribed GLP-1-based RAs therapies depending on availability

doi: 10.1016/j.phrs.2017.11.023 12 Asaduzzaman KhanMTaniaMFuSFuJ

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