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Concerningly, the lost weight tends to return when the medication is stopped

Calorie counting helps maintain a sustainable deficit while prioritizing nutrient-dense foods to prevent muscle loss, a potential side effect of rapid weight reduction

Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

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Notably, nanomedicine constitutes an exceptional opportunity to target and support drug delivery to the reproductive system and other relevant organs in both the mother and fetus, and it can effectively improve xenobiotics safety profile and minimize side effects [15]

- These findings may support early individualized dose escalation strategies for semaglutide non-responders