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A 2025 Cleveland Clinic study found that individuals with certain genetic profiles were up to 50% more likely not to lose weight on GLP-1 medications, while those with responsive profiles were up to 82% more likely to achieve significant weight loss

The GLP-1 drugs, Petersen said, could work in nonspecific ways

The Drug Enforcement Administration does not classify it as a drug of abuse

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Many peptide candidates have shown promising preclinical findings in cell and animal models