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A recent study showed that, although not approved for T1D in the USA, GLP-1RA have been increasingly prescribed in patients with T1D (i.e., from 0.3% in 2010 to 6.6% in 2023) (48)

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Cell Death and Disease DOI:10.1038/s41419-026-09108-y Abstract Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in WI-38 replicative senescent cells Cellular senescence, a complex biological process characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype, has emerged as a critical target for therapeutic development for age-related diseases

Once crystallised, these cells undergo apoptosis, which is a structured and highly regulated form of cellular breakdown