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Effects of incretin-based therapy on traditional CV risk factors Most RCTs with incretin-based therapies reported significant improvements in conventional CV risk factors such as lipids and blood pressure (Fig

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Enhanced activity of IDO enzymes (IDO-1 and IDO-2) shifts tryptophan metabolism towards the kynurenine pathway, leading to increased concentrations of kynurenic acid (KYNA) within the CNS (216220)

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While this trial showed trends toward fat loss in the treatment groups, the primary endpoint of statistically significant weight reduction compared to placebo was not consistently achieved across all dose groups, and effect sizes were more modest than hoped

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Circadian misalignment increases cardiovascular disease risk factors in humans

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