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doi: 10.1016/j.chembiol.2020.03.012 75 MixMRamnathNGomezJde GrootCRajanSDibajSet al

Human PK not established = no reliable human half-life data exists

662 Conclusions The contribution of neuroglial cells to pathophysiology of neurodegenerative diseases is complex and heterogeneous with substantial disease and disease-stage stage specificity

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Some research suggests GIP activation also has central nervous system effects that amplify the appetite-suppressing signal from GLP-1