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Description

BRECs where SIRT1 was knocked down with siRNA knockdown demonstrated an increased sensitivity to hyperglycemic stress, whereas SIRT1 overexpression, or exposure to metformin, inhibited the increase of mitochondrial ROS by upregulation of LKB1, and suppressed the expression of NF-B and the apoptosis regulator protein, Bax (193)

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Wang, Y., Lin, J., Yu, Z., Cheng, J., Cheng, J., & Cui, W

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The list of conditions where fibroblasts actively contribute to pathogenesis seems endless

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