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The area located at the C-terminus is hydrophilic due to the +2 protons, responsible for the lytic activity, for a total of +6 charges at physiological Ph (Shi et al., 2016)

demonstrated that the Nrf2 agonists 4-octyl-itaconate and clinically approved dimethyl fumarate can inhibit the replication of several types of virus, including SARS-CoV-2 68 and ZIKV by an IFN-independent pathway 67

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Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions