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In STZ-induced DN mouse kidney sections, the outer mitochondrial membrane ruptured, mitochondrial crista disappeared, ACSL4 expression was significantly increased, the levels of oxidative products were elevated, and the level of GPX4 was decreased, indicating that ferroptosis was involved in STZ-induced DN [225]

Measurement and Clinical Significance of Lipid Peroxidation as a Biomarker of Oxidative Stress: Oxidative Stress in Diabetes, Atherosclerosis, and Chronic Inflammation

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Withdrawing the needle smoothly and immediately applying gentle pressure with sterile gauze if needed

Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via ampk/sirt1-foxo1 pathway

The authors concluded that fish oil supplementation improves testicular function in males without infertility, even after taking into account the intake of other dietary supplements