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Bulk RNA sequencing revealed that gene expression changes were most pronounced in the MBH, where RAMP1/3 KO mice treated with sCT showed extensive differential expression of over 1,700 genes, while WT mice exhibited comparatively minor transcriptional shifts
The most common side effects are gastrointestinalthings like nausea, constipation, or mild bloating
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HRT can involve oestrogen only, progesterone only, or a combination of both
[9] [10] Full blood count (FBC) : May reveal macrocytic anaemia (elevated mean cell volume) and reduced haemoglobin, though these changes are not always present, especially in early deficiency