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Side effects of these medications include nausea, vomiting and diarrhea, which may compromise the mothers nutritional state in early pregnancy

A recent study tested this in mice using a low dose of GLP-1 medication small enough to have negligible effects on body weight and food consumption [10]

This suggests that maybe tirzepatide ameliorates WAT function in AS, thereby improving overall metabolism and insulin sensitivity (also demonstrated by the rapid decline insulin demand)

Bibcode:2018AnRPB..69..209W

The typical initiation regimen begins with 3 mg once daily for 30 days, primarily to improve gastrointestinal tolerability rather than for glycemic efficacy