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Integration of artificial intelligence, bioinformatics, and systems biology approaches will further aid in identifying multi-target intervention nodes and optimizing treatment strategies

Since the pancreas has abundant GAD, a direct immunological destruction occurs in the pancreas and the patients will have diabetes mellitus

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J Biol Chem 291:2137521387 Mendez M, Folgado J, Tormo C, Artero A, Ascaso M, Martinez-Hervs S, Chaves FJ, Ascaso JF, Real JT (2015) Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects

Various delivery systems have been developed to enhance their efficacy and overcome limitations, as summarized in Table II with the overall goal of restoring visual clarity