Most side effects are mild and may diminish over time, but its important to discuss any concerns with your healthcare provider
The SURMOUNT-1 trial demonstrated average weight reductions of 15-22.5% of body weight over 72 weeks
Moreover, TRF, as we used in our study, is generally well tolerated in humans, with high adherence and limited discomfort caused by this fasting pattern 33
For more on this, see our guide to A Medical Guide to NAD+ Precursors: Understanding NR, NMN, and Your Cellular Health, and how it is evaluated and treated at Perfect B in Doral
The pathogenesis of GERD has not yet been clarified
Cloning of expression plasmids and bacterial transformations The oligonucleotides used in this study were obtained from Metabion (Planegg/Steinkirchen, Germany) and are listed in Table S4