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Studies show that IDH1/2 syntheses isocitrate/citrate from -KG with NADPH consumption, then the isocitrate/citrate import into the mitochondria and contribute to suppress mitochondrial ROS

p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

Yes, BPC-157 can often be used alongside antibiotics, but it should be done under medical supervision

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