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Mechanism of Action The Triple G Pathway Retatrutide is a triple G agonist, acting on three key pathways: GLP-1 reduces appetite GIP supports metabolic signaling Glucagon receptor increases energy expenditure Triple G Pathway Retatrutide activates all three simultaneously The Role of Glucagon What makes retatrutide different from earlier therapies is glucagon activation

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This includes when to increase dose, what side effects to watch for, and when labs will be repeated

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