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4.5 Clinical implications 4.5.1 Sting agonists Given the complex involvement of STING signaling in the cancer immunity cycle and its capability to induce an anti-tumor immune response, efforts have been made to develop new STING agonists

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Such variability creates significant challenges for reproducibility particularly as few studies systematically evaluate how source material variability affects CQD composition and performance

Further, the extraordinary affinity of HGF for Dihexa (Kd=2.2 x 10 "13 M) suggests that normally non- biologically active levels of HGF become physiologically relevant in the presence of a high affinity mimetic