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doi:10.1515/BC.2003.067

This may last for a few weeks

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They are larger and more complex, and the larger they get, the harder it is for them to cross the lining of the mouth in any useful amount

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We lean towards the conclusion that in cells, colistin-induced permeability transition might occur because of the direct interaction with the mitochondria as well as upon prolonged release of Ca 2+ from the ER lumen