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This was confirmed by preincubation of (2 S ,3 S )- t -ES- a9 - b7 with cathepsin B for 30 min at ten times the IC 50 , which completely inactivated cathepsin B when assayed with fluorogenic substrate following 100-fold dilution 57 (Supplementary Fig

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Eighty-one percent of patients randomized to LANTUS were using LANTUS at end of the study