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It is important to be clear that these findings come largely from preclinical (animal and cell) models, and that a described mechanism is not the same as a proven result in people

This paradox suggests that inhibiting AhR to alleviate renal injury may inevitably compromise the protective immune barrier of the intestine, thereby undermining the clinical application of the gut-kidney axis theory (73)

Bousquet, J., Bousquet, P

Insight from imaging on plaque vulnerability: similarities and differences between coronary and carotid arteries-implications for systemic therapies

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Subsequent studies revealed heightened sensitivity of MM cell lines to ferroptosis, with combined bortezomib and iron chelation exhibiting superior efficacy in suppressing disease progression compared to monotherapy, these findings collectively underscore the critical role of ferroptosis in MM pathogenesis (Figure 3)