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Since biotin is water-soluble, any extra in your body flushes out through the urine, so overdose is highly unlikely
Individual responses to timing vary considerably, and there is no clinical evidence that nighttime administration reduces gastrointestinal side effects compared to other times of day
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Patients need refills because these compounds are administered as weekly or bi-weekly intramuscular injections, and each vial contains a finite number of doses
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