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First, the engineering of vector capsids and the selection of serotypes are widely used to enhance the transduction efficiency of cartilage tissue

10,11,81,82 Specifically, TLR-2, TLR-4, and the myeloid differentiation primary response protein 88 (MyD88) are crucial to the inflammatory reaction of macrophages to uric acid crystals

In 1948, Takahara, a Japanese otolaryngologist, first reported this disorder [133, 134]

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This method allows the antioxidant to be absorbed into the bloodstream through the muscle's rich blood supply, bypassing the digestive system for higher bioavailability