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Understanding these fundamental effects on digestion helps contextualize why some patients and practitioners consider supplemental digestive enzymes during treatment, though the evidence base for this practice requires careful examination

However, their widespread clinical use will depend on rigorous safety evaluation, standardized manufacturing, and clearer regulatory pathways

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Over time, it may cause changes in fat tissue, known as lipodystrophy, which can appear as lumps or dips under the skin

doi: 10.1007/s00394-004-0486-y

Sestrin 2 is a leucine sensor that inhibits mTORC1 signaling [87], providing an interesting link between amino acid sensing, mTOR, and NRF2-KEAP1 pathway