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Additionally, a one-year placebo-controlled trial in adults aged 65 years and older found that daily supplementation with a multivitamin/mineral did not benefit cognitive performance on a verbal fluency test an assessment in which participants were asked to list words starting with a certain letter in a designated time period (135)

doi: 10.1111/j.1747-0285.2005.00318.x

Compounded/Injectable GHK-Cu: Not FDA-approved for systemic use

Accessed 11 June 2026

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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed