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Although the overall number of CD4+ T cells can initially regenerate, different subsets of CD4+ T cells (i.e., Th1, Th2, Th17, Treg, etc.) are disproportionately depleted and never return to homeostatic levels [12]

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In transgenic models, it reduced fibril formation by 62% and striatal deposits by 41%, while also improving motor function without eliciting significant immunogenicity

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