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The most common adverse effects are gastrointestinal, including nausea, vomiting, and diarrhea

That usually includes consuming only clear liquids for 1 to 3 days before your colonoscopy

The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load

Ethics declarations Competing Interests The authors declare no competing interests

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