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The SURMOUNT-1 trial extension, the longest completed study to date, followed participants for three years (176 weeks)

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Available online at: 2 MartensHHeeseSBothmannCGtzH-JRichterT

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Compared to placebo, men who took the multiple vitamin-mineral supplement for 33 days had significantly improved ratings on one (vigor-activity score) of the six components of the Profile of Mood States (POMS) scale, significantly reduced subjective stress as measured by the Perceived Stress Scale, and significantly improved self-ratings of mental tiredness prior to and following a battery of cognitively demanding tasks (134)

Screening of 16,675 titles and abstracts led to the removal of 15,778 non-relevant studies