B12 deficiency can also be an issue if you have had weight loss surgery, have a very poor diet, or follow extreme or restrictive diets for a long time
This effect is caused by semaglutide reprogramming immune cells and macrophages via the GLP-1R/PPARG/ACSL1 pathway, also causing anticancerous effects in rodents (9)
doi: 10.3389/fimmu.2019.01026 46 XuYShenJRanZ
Clinical data shows reductions in VAT beginning within 1 to 2 weeks, with substantial changes evident by 8 to 12 weeks of daily 2mg subcutaneous injections
Regular use can make it easier to stick to a healthier diet, which may result in lasting changes
Management strategies: Rotate injection sites consistently Allow alcohol to dry completely before injecting Inject at room temperature (not cold from the fridge) Use a fresh needle every time If reactions persist or worsen, see injection site reaction with tirzepatide , tirzepatide injection site red and itchy , and tirzepatide injection site reaction treatment