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67 A Bayesian network meta-analysis pooled data from 54 RCTs involving 49 602 participants, of whom 28 353 received GLP-1 RA treatment demonstrated that GLP-1 RAs were associated with a reduced risk of fractures compared to placebo or other antihyperglycemic agents

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Because it's swallowed rather than injected, absorption is less predictable than the injectable form, which is why your provider monitors your response closely

Appetite suppression is more consistent and pronounced

Visceral fat and insulin resistance can reinforce each other, creating a cycle that worsens metabolic health