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Yet CNS drug development faces a daunting success rate of less than 10%, predominantly due to the brains formidable defense system: the blood-brain barrier (BBB)

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The complete titration schedule from a 10 mg vial Nobody starts at the full dose

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Despite the promising results, the studys main limitation lies in its patient selection process, which was based solely on symptoms rather than objective measures of reflux and extra-esophageal manifestations