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In addition, the cancer suppressor p53 downregulates SLC7A11 expression to inhibit System Xc function, reduce GSH synthesis, finally increase cellular sensitivity to oxidative stress, which is not required GPX4 (Wan et al, 2023)

Okayama H, Aikawa T, Okayama M, et al

Glutathione molecules have their own life cycle. As glutathione (GSH) is utilized and oxidized, it becomes oxidized glutathione (GSSG)

A phase III study (NCT02965716) aims to assess the effectiveness of talimogene laherparepvec (T-VEC) in combination with pembrolizumab (MK-3475) in treating patients who have progressed on prior anti-PD-1 or anti-PD-L1 therapy, either alone or in combination with other drugs other than talimogene laherparepvec (T-VEC) [213]

In the end, it is necessary to determine how to optimize the selection of appropriate linkers, targets, and toxic molecules through case by case analysis to balance the effectiveness and toxicity of ADC drugs

For N-acetyl epithalon amidate (Ac-AEDG-NH2)