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doi: 10.1017/S0031182099004564 24 JemaM.FezaiM.BissingerR.LangF

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doi:10.1002/prot.24208

Abbreviations CQ: Chloroquine CSCs: Cancer stem cells ER: Estrogen receptor-alpha GPxs: Glutathione peroxidases GSH: Glutathione HCC: Hepatocellular carcinoma hiPSC-MSCs: Mesenchymal stem cells drived from human induced pluripotent stem cells IBC: Inflammatory breast cancer IH: Isorhamnetin LOH: Loss of heterozygosity MnSOD: Manganese superoxide dismutase NAC: N -acetylcysteine PHGPx: Phospholipid GPx ROS: Reactive oxygen species TNBC: Triple-negative breast cancer TFAP2C: Transcription factor AP-2 gamma References Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A

Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

Cancer cells derived EVs also contain several miRNAs and lncRNAs, and studies have extensively reported on the involvement of these miRNAs and lncRNAs in the transmission of drug resistance phenotypes and the extension of drug resistance to several drugs, such as DOX, gefitinib, erlotinib, trastuzumab, and cisplatin (311316)