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These drugs fall within two categories: human GLP-1 backbone agents (that is, albiglutide, dulaglutide, liraglutide and semaglutide) and exendin-4 backbone agents (that is, exenatide, lixisenatide and tirzepatidethe latter activating both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors) 1
MASH (metabolic dysfunction-associated steatohepatitis) is a serious fatty liver disease that scars the liver as it advances
Keywords: GLP-1, pediatric obesity, cell signaling, development, microbiota, molecular pharmacology GLP-1, glucagon-like peptide-1
Gregor MF, Hotamisligil GS
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