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ZIP7, localized to the ER, is also highly expressed in the intestinal crypts

In pan-cancer copy number variation (CNV) and mutation analyses from the TCGA database, 456 most of the SLC30 and SLC39 family genes demonstrated gene amplification, especially SLC30A8 , SLC30A1 , SLC30A10 , SLC39A1 , and SLC39A4

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However, it should be noted that CYP2E1-dependent ethanol oxidation activity is at least twice that of either of the other two enzymes