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Ceruloplasmin fluctuates under certain conditions of physical stress, such as trauma, inflammation, and disease

Proc Intl Soc Mag Reson Med

Patients with Chronic Pulmonary Disease: Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets (see WARNINGS, Life-Threatening Respiratory Depression)

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Unlike IV infusion, subcutaneous administration eliminates the flushing, nausea, and chest tightness that IV protocols can produce when infused too rapidly