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Testosterone production is governed by the Hypothalamic-Pituitary-Testicular Axis (HPTA)

22(1):5374 The somatomedin hypothesis and insulin-like growth factor signaling in endocrine regulation Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, Le Roith D., Journal of Clinical Investigation , 2001

MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction

Hypoglycemia IGF-1 has insulin-like properties and can reduce blood sugar levels, especially when combined with insulin or carb restriction

Immunogenicity also was evaluated by measuring the development of antibodies to heterologous proteins

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