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External factors, including pollution, toxins, lifestyle choices, and dietary habits, also contribute to oxidative stress and can significantly impact sperm quality and fertility outcomes

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Molecular analysis was conducted to assess the activation of the Nuclear factor erythroid 2-related factor (Nrf2)/Heme oxygenase 1 (HO-1) signaling pathway

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It also enhances ease of administration and maintains patient comfort

Importantly, FOXO4-DRI achieves these effects with favorable treatment kinetics compared to approved medications like pirfenidone, suggesting potential for more efficient therapeutic intervention