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A team of investigators found that the expression of OPTN was significantly reduced in renal biopsies of patients with type 2 DKD, and OPTN was found to suppress the activation of NLRP3 inflammasomes by enhancing mitophagy on HG-induced renal tubular epithelial cell (RTEC) model in mice thus playing a therapeutic role in DKD [124]

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Nature Reviews Cancer (2008) 9

Laura Schaefer Laura Schaefer is the author of The Teashop Girls , The Secret Ingredient , and Littler Women: A Modern Retelling