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The researchers concluded that long-term body mass loss is only partially mediated by caloric restriction melanocortin system activation appears to increase energy expenditure independently (Cote et al., 2017)

References Lin Xi, et al

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There is some evidence to suggest that patients receiving methotrexate, commonly used in rheumatoid arthritis, are at increased risk of nonmelanoma skin cancer, possibly due to the photosensitizing nature of methotrexate

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