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Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus

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Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome

Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]

[PubMed: 38992799] 56

A permanent microdose strategy with promises of same results, less drug is not backed by randomized trials